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Updated: Jan 9, 2026

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
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超强增强器驱动的核心转录因子FOXP1通过相分离介导的SESN3激活延迟内皮细胞衰老

Lushuang Mao1,2, Zhao-Fu Liao1,2, Dong Tang1,2

  • 1Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, P.R. China.

Theranostics
|December 8, 2025
PubMed
概括

在超强增强剂中,FOXP1蛋白经历液-液相分离 (LLPS),通过激活SESN3和抑制mTORC1信号,延迟内皮细胞衰老并抑制动脉样硬化.

关键词:
这就是FOXP1P.内皮细胞衰老 细胞衰老表观遗传调节 表观遗传调节液态-液态相隔离方法 液态相隔离方法这是一个超级增强器.

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