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通过瘤微环境重塑和ROS放大增强增强放射治疗的纳米敏感剂

Junchao Qian^1,2,3, Yijun Lu^1,3, Dandan Wang³

¹Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, P.R. China.

|December 8, 2025

概括

这项研究介绍了GMCN@PEG纳米粒子,通过增加活性氧物种 (ROS) 和减少瘤缺氧来增强放射治疗. 这些纳米粒子还重新编程瘤微环境,以提高抗瘤免疫力和改善成像.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

放射治疗是癌症治疗的关键,但受到低反应性氧物种 (ROS),瘤缺氧和免疫抑制性瘤微环境 (TME) 的限制.
放大ROS和修改TME的策略对于提高放射治疗疗效至关重要.

研究的目的:

设计和评估聚乙烯糖醇 (PEG) 修饰的黄金@二氧化核心外纳米颗粒 (GMCN@PEG) 用于增强放射治疗和双模式成像.
调查GMCN@PEG减轻瘤缺氧,放大ROS和调节TME的能力.

主要方法:

开发了对酸性TME有反应的GMCN@PEG纳米粒子.
评估了GMCN@PEG的生物相容性,ROS放大,低氧减轻和免疫调节作用在体外和体内.
评估了GMCN@PEG在增强放射治疗灵敏度和MR-CT双模成像方面的性能.

主要成果:

GMCN@PEG表现出良好的生物相容性,有效缓解瘤缺氧,同时在酸性TME中放大ROS.
GMCN@PEG增强了放射治疗的敏感性,诱导了免疫细胞死亡 (ICD),并激活了cGAS-STING通路.
GMCN@PEG促进了树突细胞的成熟,M1巨细胞的极化,T细胞的透,并改善了MR-CT成像.

结论:

GMCN@PEG作为一个多功能纳米敏感剂,具有显著的潜力来提高放射治疗的疗效.
GMCN@PEG重塑TME,增强抗瘤免疫力,并改善生物医学成像.
GMCN@PEG整合了诊断和治疗,为晚期癌症治疗提供了一种有前途的方法.

关键词:

两种模式的 MR-CT 双模成像技术.ROS 的放大效果是 ROS 的放大效果金@二氧化核心外纳米颗粒缺氧缓解减轻缺氧的影响辐射疗法辐射疗法

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