基于化学动力学和代谢重编程的协同化学和代谢癌症治疗,使用CuO@HA纳米酶与氧气空缺
Weiwei Wang1, Yuxuan Cai1, Zhongxing Wang2
1Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Theranostics
|December 8, 2025
概括
这项研究引入了CuO@HA纳米酶,通过产生有毒基基和改变氨基酸代谢来重新编程瘤微环境,有效地抑制癌症生长,毒性最小.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤微环境 (TME) 给癌症治疗带来了挑战,原因是代谢,酸性和高甲 (GSH) 和过氧化 (H2O2) 水平的乱.
- 具有多酶活性的纳米酶为TME重编程和瘤抑制提供了潜力.
研究的目的:
- 为了开发一个层次的CuO纳米酶,用氨酸 (CuO@HA) 装饰,用于TME重塑.
- 在体外和体内研究CuO@HA的抗瘤作用和潜在机制.
主要方法:
- 用装饰的氨酸制造CuO@HA纳米酶.
- 使用酶动力学和密度功能理论 (DFT) 评估类似过氧化酶 (POD) 和类似谷氨氧化酶 (GSHOx) 的酶活性.
- 在体外和体外抗瘤功效的评估和通过多组方法的机制性探索.
主要成果:
- CuO@HA表现出有效的POD类和GSHOx类活性,催化H2O2分解为基基 (·OH) 和GSH氧化为GSSG.
- DFT证实了CuO@HA.的催化效率.
- 在体外和体内,CuO@HA通过产生OH和重编程甘氨酸,血清素和三胺代谢来抑制乳腺癌和黑色素瘤细胞的生长,没有显著的全身毒性.
结论:
- 这项研究提出了一种新的策略,使用CuO纳米颗粒通过降低胆脱酶 (Chdh) 的调节来重新编程甘氨酸,氨酸和氨酸代谢.
- 化学动力学治疗和氨基酸代谢重编程的结合方法为癌症治疗提供了一个有前途的新途径.
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