层:一个量化可解释的人工智能框架来解码肌肌腰部疼痛的组织层驱动因素
Zixue Zeng1,2, Anthony M Perti1, Tong Yu1,2
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.
ArXiv
|December 8, 2025
概括
肌肌关节疼痛 (MP) 研究往往忽略了非肌肉组织. 我们的AI框架,LAYER,揭示了筋膜和脂肪对腰部疼痛预测有显著的贡献,挑战了以肌肉为中心的观点.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 肌肌关节疼痛 (MP) 是慢性腰部疼痛的主要原因之一.
- 目前的研究缺乏可靠的生物标志物,主要关注肌肉,忽视其他软组织.
研究的目的:
- 开发和验证一个可解释的AI框架 (LAYER) 来分析软组织对MP的贡献.
- 用3D超声波识别特定的组织层及其在MP预测中的作用.
主要方法:
- 开发了LAYER,这是一种用于分层分析的AI框架,用于产生可解释的相关组织.
- 分析了6个组织层的4000多个3D超声波扫描.
- 使用B模式和剪切波成像对MP预测进行量化组织层贡献.
主要成果:
- 非肌肉组织,特别是深膜 (DFM),对MP预测有显著的贡献.
- 非肌肉层的集体突出度几乎与联合成像中的肌肉突出度相匹配.
- 在B模式成像中,LAYER在B模式成像中显示了DFM的高突出性 (0.420).
结论:
- 挑战了肌关节疼痛研究中传统的以肌肉为中心的模式.
- 突出了带和其他非肌肉组织在腰部疼痛中的重要性.
- 为软组织成像分析提供了新的,可解释的框架,并确定了新的治疗点.
更多相关视频
05:10Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
Published on: August 30, 2022
3.4K
06:28Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
Published on: December 13, 2024
1.1K
相关概念视频
Dense Connective Tissue
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Layers of Connective Tissue Proper
Fascia, a thin layer of fibrous connective tissue, is distributed throughout the body. It demarcates and forms a supportive covering over skeletal muscles, bones, blood vessels, and organs. There are three main types of facia— superficial fascia, deep fascia, and subserous fascia. These are all present at different depths in the body. Fascia reduces the friction and permits muscles, joints, and organs to easily slide against each other, facilitating movement of the body and preventing tearing...
Muscles of the Vertebral Column
The back muscles that lie deep into the thoracolumbar fascia are called intrinsic or true back muscles. These muscles are divided into four layers: superficial, intermediate, deep, and deepest layers.
Superficial Layer:
The superficial layer consists primarily of the splenius muscles, which include the splenius capitis and splenius cervicis. These muscles are mainly responsible for the head and cervical spine movements, including extension, rotation, and lateral bending. The splenius capitis...
Superficial Layer:
The superficial layer consists primarily of the splenius muscles, which include the splenius capitis and splenius cervicis. These muscles are mainly responsible for the head and cervical spine movements, including extension, rotation, and lateral bending. The splenius capitis...
![Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58491.jpg&w=3840&q=50)