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预测分析BRAFV600E突变和中央淋巴结转移在乳头甲状腺癌的乳头甲状腺癌

Junhui Peng¹, Zhihui Wu¹, Yujun Huang²

¹Department of General Surgery, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, Guangdong 528300, P.R. China.

Oncology letters

|December 8, 2025

概括

带有BRAF V600E突变的乳头甲状腺癌 (PTC) 表明中枢淋巴结转移的风险更高. 手术前的BRAF V600E测试有助于精确的风险分层和个性化的患者手术规划.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

甲状腺癌的发病率正在上升,乳头甲状腺癌 (PTC) 是常见的.
中枢淋巴结转移 (CLNM) 在PTC显著影响患者的复发和生存.
准确的手术前 CLNM 风险评估对于有效的患者管理至关重要.

研究的目的:

在PTC中确定CLNM的临床和分子预测因子.
调查BRAF V600E突变在预测CLNM中的作用.
为CLNM风险分层开发一个个性化的名图.

主要方法:

从癌症基因组图谱 (TCGA) 中分析基因表达特征和临床数据.
识别与BRAF V600E相关的差异表达基因 (DEG).
使用追溯细针吸收细胞学 (FNAC) 和免疫组织化学标本进行验证.

主要成果:

BRAF V600E突变非常普遍,并且与CLNM风险增加有关.
年龄,瘤大小和BRAF V600E状态是CLNM的独立预测因素.
一个整合这些因素的名图实现了0.710.0的ROC.

结论:

通过FNAC进行BRAF V600E测试可以改善PTC中手术前CLNM风险分层.
综合性手术前评估,包括BRAF V600E状态,支持个性化手术规划.
患有TI-RADS ≥4a结节和没有放射性LNM的患者可能会从这种方法中受益.

关键词:

在BRAF V600E突变中.中枢淋巴结转移的转移.这个名字是名ogramogram.皮囊甲状腺癌皮囊甲状腺癌风险因素的风险因素是什么

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