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在日本老年患者中,C反应性蛋白/白蛋白比率与死亡率之间的关联,这些患者患有中风后失足症

Ziying Wang¹, Lingling Wang²

¹Department of Postgraduate, School of Clinical Medicine, Beihua University, Jilin, China.

Frontiers in neurology

|December 8, 2025

概括

反应性C蛋白/白蛋白比率 (CAR) 预测了日本老年患者中脑卒中后失足症 (PSD) 的死亡率. 虽然CAR与死亡风险增加有关,但白蛋白在预测1年死亡率方面略有改善.

科学领域:

老年学是指老年学的学科.
临床医学临床医学
生物标志物生物标志物

背景情况:

脑卒中后失足症 (PSD) 在老年患者中很常见,增加死亡风险.
C-反应蛋白/白蛋白比率 (CAR) 是一个潜在的预后标志物,但其在PSD死亡率中的作用还未得到充分研究.
很少有研究评估了PSD的日本老年患者的CAR.

研究的目的:

评估C反应性蛋白/白蛋白比率 (CAR) 作为PSD的日本老年患者死亡率的预后因素.
为了比较CAR与C反应蛋白 (CRP) 和专蛋白对死亡率的预测性能.
评估CAR与该人口的一年死亡率之间的关联.

主要方法:

对133名患有PSD的日本老年患者 (2014-2017年) 的回顾性队列研究.
考克斯比例危险模型用于评估CAR,CRP和白蛋白与死亡率的关联.
卡普兰-梅尔曲线用于CAR地球动物的生存和ROC曲线用于1年死亡率预测.

主要成果:

在完全调整后,每增加1个单位的CAR都与49%的死亡风险增加有关 (HR 1.49).
较高的CAR三角动物的生存率明显较差.
卡尔显示了适度的1年死亡率歧视 (AUC=0.702);白蛋白 (AUC=0.710) 提供了较小的额外预测益处比卡尔 (IDI=0.108,NRI=0.217).

结论:

在日本老年PSD患者中,CAR与死亡率有积极关联.
在这个群体中,CAR对1年死亡率具有适度的预测价值.
专提供了轻微的增量预测效益;需要更大的前性研究来验证.

关键词:

在C-反应性蛋白/白蛋白的比率.失足症是一种失足症.老年人是人口中的老年人.死亡率死亡率一次性中风中风中风中风中风

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