巨细胞向的细胞微粒协同抗结核治疗,结合CircRNA介导的宿主免疫防御和杀死抗生素
Yuhe Ma1,2, Fen Yang1,2, Juan Liu1,2
1Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, China.
Materials today. Bio
|December 8, 2025
概括
这项研究开发了一种新的纳米粒子系统,将circRNA TRAPPC6B和利芬素结合起来,以向巨细胞. 这种方法增强了免疫系统和抗生素作用,使结核病治疗更有效,病理性减少.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 由Mycobacterium tuberculosis (Mtb) 引起的结核病 (TB) 是全球主要的传染病.
- 目前的结核病治疗需要提高抗生素疗效和增强宿主免疫反应.
- 循环RNA TRAPPC6B (circTRAPPC6B) 显示出促进巨细胞自和M1极化为细胞内Mtb清除的潜力.
研究的目的:
- 开发一种针对巨细胞的新型纳米系统,用于协同治疗结核病.
- 为了将circTRAPPC6B的免疫调节作用与里芬素的杀菌作用相结合.
- 在Mtb感染模型中评估工程纳米系统的有效性和安全性.
主要方法:
- 工程化细胞向的细胞微粒 (MPs) 封装了circTRAPPC6B和利芬素 (Gal-CircRNA@Rif@MPs).
- 利用银河糖表面功能来选择性地准巨细胞.
- 评估了纳米系统对巨细胞自,M1极化,细胞内Mtb清除和Mtb感染小鼠治疗结果的影响.
主要成果:
- 该Gal-CircRNA@Rif@MPs纳米系统证明了对巨细胞的选择性向.
- 细胞内CircTRAPPC6B水平的增加促进了巨细胞的自和抗菌两极分化.
- 该纳米系统通过结合向的利芬素输送和宿主免疫防御,协同增强了Mtb杀死,显著减少了Mtb负担和肺病理,毒性最小.
结论:
- 具有免疫调节性质的循环RNA可以有效地与使用细胞微粒用于向MTB清除的抗结核药物结合.
- 开发的Gal-CircRNA@Rif@MPs系统为同步抗生素作用和对结核病的宿主免疫防御提供了一个有希望的策略.
- 这种方法代表了一种针对宿主细胞的新型治疗系统,用于推进抗结核病治疗,以改善结果和安全性.
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