温和的光热介导的神经免疫调节复合液凝改善骨愈合的微环境,增强骨质疏松性骨缺陷再生
Qingcheng Song1,2,3,4, Shuo Zhang5, Jiahao Yu1,2,3,4
1Department of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050051, China.
Materials today. Bio
|December 8, 2025
概括
一种新的复合水凝 (Ce@Mo/GC) 通过清除活性氧物种 (ROS),调节免疫反应,促进骨再生,血管生成和神经修复,有效治疗骨质疏松性骨缺陷.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
背景情况:
- 骨质疏松性骨缺陷由于氧化应激和炎症而带来重大骨科挑战.
- 目前的骨移植材料难以协调骨愈合的复杂生物过程,包括免疫调节,血管生成,骨质生成和内化.
研究的目的:
- 开发一种多功能复合水凝 (Ce@Mo/GC),用于优化骨质疏松性骨缺陷中的骨质原生微环境.
- 调查水凝调节免疫反应的能力,促进血管新生,骨质新生和神经新生,以增强骨愈合.
主要方法:
- 制造一个CeO2@Mo2Ti2C3 MXene (Ce@Mo) 异构连接,并纳入一个凝甲基烯 (GelMA) /碳氧甲基基 (CMCS) 水凝 (Ce@Mo/GC).
- 评估Ce@Mo/GC的类似酶的活动,NIR响应的光热效应,ROS清理和巨细胞极化 (M2表型).
- 在体外和体内研究以评估生物相容性,抗炎作用,骨质分化,血管生成和神经生成促进.
主要成果:
- Ce@Mo/GC水凝通过光热增强的Ce3+/Ce4+转换表现出有效的ROS清理,并促进了M2巨细胞的极化.
- 局部使用Ce@Mo/GC诱导神经发生和时空神经释放通过轻度光热刺激.
- 在体外和体内实验证实了水凝的生物相容性及其调节炎症的能力,促进骨质生成和血管生成,并促进神经免疫调节以促进骨愈合.
结论:
- 多功能Ce@Mo/GC水凝为骨质疏松性骨缺陷提供了一个有前途的治疗策略.
- 这种生物材料有效地协调了全面骨再生所必需的多种生物过程.
- 该研究强调了综合生物材料设计在解决复杂的骨科挑战方面的潜力.
相关概念视频
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...