口腔微生物组作为吸烟和全因死亡率之间的关联中介
Yue Xu1,2, Xin Leng3,4, Qi Liu1,2
1Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, People's Republic of China.
Journal of oral microbiology
|December 8, 2025
概括
吸烟会缩短寿命,但口腔微生物群的多样性起着复杂的作用. 增加微生物多样性可能部分抵消吸烟.
科学领域:
- 微生物组研究的研究.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 吸烟是已知的死亡风险因素之一.
- 吸烟对口腔微生物群的影响及其对死亡率的调解作用尚未完全理解.
研究的目的:
- 调查口腔微生物群多样性是否调解吸烟与全因死亡率之间的关联.
主要方法:
- 利用了8223名参与国家健康和营养检查调查的数据.
- 使用alpha和beta多样性指标评估口腔微生物群多样性.
- 雇员Weibull加速失效时间模型和调解分析来检查协会.
主要成果:
- 目前的吸烟与42.3%的生存时间减少有关.
- 更高的口腔微生物操作分类单位 (OTU) 丰度与33.2%的生存时间增加有关.
- 调解分析表明,口腔微生物群多样性部分调解了吸烟与死亡率之间的关系.
结论:
- 口腔微生物群的多样性部分介绍了吸烟与死亡率之间的联系.
- 虽然吸烟会降低生存率,但增加微生物多样性可能会产生保护作用.
- 对微生物机制和干预措施的进一步研究是有必要的.
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