单细胞RNA序列分析显示USP32是缓解PD-L1驱动的结直肠瘤发生的治疗标in vitro和in vivo

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Girish Birappa1, Haribalan Perumalsamy2,3, Seok-Ho Hong4

  • 1Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea.

Theranostics
|December 8, 2025
PubMed
概括

研究人员将USP32确定为一个关键的二化酶 (DUB),该酶在结肠直肠癌 (CRC) 中稳定了编程死亡连接体1 (PD-L1). 向USP32可降低PD-L1,抑制CRC细胞的增殖和瘤发生.

关键词:
癌症进展 癌症进展没有二维基因酸酶.通过多元化化化.预后标志物是一个预后标志物.蛋白质的丰富性 蛋白质的丰富性蛋白质降解 蛋白质降解蛋白质营业额的变化转录组分析 转录组分析

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