间歇性禁食通过肠-大脑轴对大脑健康的影响
Ziqian Zhao1,2, Wenting Geng3, Yan Gao1
1Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Frontiers in nutrition
|December 8, 2025
概括
间歇性禁食 (IF) 通过调节肠-大脑轴来增强大脑健康. 这种饮食方法可以减少神经炎症并改善认知功能,为神经和精神疾病提供一种新的非药物治疗策略.
科学领域:
- 营养神经科学 营养神经科学
- 肠-大脑轴研究研究
- 神经保护策略 神经保护策略
背景情况:
- 神经和精神疾病是全球健康的重大负担.
- 间歇性禁食是一种新兴的饮食策略,具有潜在的治疗益处.
- 肠-大脑轴在维持大脑健康和功能方面发挥着至关重要的作用.
研究的目的:
- 审查关于IF神经保护和心理健康益处的临床前和临床证据.
- 探索IF调节肠道微生物群-代谢物-大脑轴的机制.
- 确定未来的研究方向,以优化IF协议.
主要方法:
- 关于IF对肠道微生物群,神经炎症和认知功能的影响的临床前研究综合.
- 分析临床证据,将IF与阿尔茨海默氏症和帕金森病标志物联系起来.
- 检查IF对肠道微生物群组成和代谢物产生的影响.
主要成果:
- IF丰富益生菌,减少神经炎症,并改善肠道屏障的完整性.
- 在多发性硬化症模型中,IF的原效应提高了线粒体效率,并降低了T细胞活性.
- 在阿尔茨海默氏症模型中,IF与降低的β-粉样蛋白相关,在帕金森病患者中改善了运动功能.
- IF重新平衡肠道微生物群,可能通过血清素合成帮助缓解焦虑和抑郁症.
结论:
- 间歇性禁食通过调节肠-大脑轴提供多模式的神经保护和心理健康益处.
- 调节肠道微生物群,代谢物和炎症途径是关键机制.
- 个性化IF协议对于未来的治疗应用至关重要.
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