炎症和营养参数对心血管多发症死亡率的影响:基于两个数据集的综合预后分析
Ziqi Chen1, Aijing Zhu2, Xu Zhu1
1State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology, the First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
Frontiers in nutrition
|December 8, 2025
概括
系统性炎症反应指数 (SIRI) 是心血管多病症 (CMM) 患者死亡率的强有力的预测指标. 较高的SIRI水平表明所有原因和心血管死亡的风险增加,有助于风险分层.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 心血管多病症 (CMM) 是一个日益增长的全球健康挑战,与过早死亡有关.
- 系统性炎症是心脏代谢疾病的关键因素,但其在CMM的预后价值尚未完全理解.
研究的目的:
- 研究CMM患者的炎症和营养生物标志物的预后影响.
- 确定死亡率的最佳预测因素,并为CMM患者开发预测模型.
主要方法:
- 分析了来自NHANES的1928名CMM患者和来自中国队列的364名患者.
- 评估十个炎症和营养参数,包括全身炎症反应指数 (SIRI).
- 应用多变量考克斯回归,特征选择技术,名录和机器学习 (ML) 模型进行预测.
主要成果:
- 确定SIRI是所有原因和心血管死亡率最强的独立预测因素.
- 升高的SIRI水平显著增加了死亡风险,在各个子组中发现一致的结果.
- 诺米图和ML模型,特别是XGBoost,显示出对死亡率的高预测准确性.
结论:
- 在CMM患者中,SIRI作为死亡风险分层的有价值生物标志物.
- 经过验证的诺姆图和预测工具为个性化预后提供了实际的临床实用性.
- 研究结果支持针对全身炎症和营养,以改善CMM管理.
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