脉冲波速度与大脑小血管疾病之间的关联:一个范围审查
Zaneh Kahook1, Oren Nedjar1, Amanda Escudero1
1Osteopathic Medical School, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Cureus
|December 8, 2025
概括
通过脉冲波速度 (PWV) 测量的动脉硬度与脑小血管疾病 (CSVD) 标志物 (如白质过强度) 有关. 这种关联可能有助于预测老年人群的认知衰退和中风风险.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 大脑小血管疾病 (CSVD) 是中风和痴呆的常见原因,随着年龄的增长而增加.
- 早期CSVD检测的非侵入性预测因子对于及时干预至关重要.
- 通过脉冲波速度 (PWV) 评估的动脉硬是潜在的标志物,但它与CSVD的关系是复杂的.
研究的目的:
- 为了澄清脉冲波速度 (PWV) 和大脑小血管疾病 (CSVD) 生物标志物之间的关联.
- 审查有关PWV和主要CSVD指标的现有文献,包括白质超强度 (WMH) 和缺口性心脏病发作 (LI).
主要方法:
- 对4个数据库 (EMBASE,MEDLINE,Web of Science,CINAHL) 进行了范围审查.
- 包括2014年至2024年间发表的同行评审的英语文章.
- 专注于与CSVD生物标志物一起测量PWV的研究:WMH,LI,微分异性质 (FA),大脑微型血液 (CMB) 或周围血管空间 (PVS).
主要成果:
- 在1345篇最初的文章中,有53篇符合纳入标准.
- 较高的PWV通常与WMH增加,PVS严重程度增加,FA降低和LI存在相关.
- 在PWV和WMH存在之间观察到最强的关联.
结论:
- PWV显示出作为CSVD严重程度和进展的早期预测器的潜力,特别是当标准化时.
- PWV-CSVD链接与认知能力下降,中风风险和抑郁症有关.
- 在管理CSVD和改善结果方面,PWV可以作为可修改的风险因素.
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