老年人治疗耐药双极性抑郁症的挑战:成功增强莫达菲尼尔的案例研究
Arinze Mbanusi1, Muhammad-Kazim Kanani1
1Mental Health Services for Older People, Lanchester Road Hospital, Tees, Esk and Wear Valleys NHS Foundation Trust, Durham, GBR.
Cureus
|December 8, 2025
概括
莫达菲尼尔作为治疗耐药双极性抑郁症 (TRBD) 的辅助治疗在老年人中具有前景. 这项案例研究发现,modafinil在TRBD和并发性疾病的老年患者中改善了情绪和清醒.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年病的医生 老年病的医生
背景情况:
- 耐治疗双极性抑郁症 (TRBD) 存在重大挑战,特别是在患有并发症的老年患者中.
- 由于老年人的药物耐受性问题,存在有限的治疗选择.
研究的目的:
- 评估modafinil作为TRBD的辅助治疗在患有多种并发症的老年患者中的疗效和耐受性.
- 探索modafinil在常规治疗无效或禁用的情况下的潜在实用性.
主要方法:
- 一个74岁的男性长期患有双相情感障碍和并发性疾病 (CKD,小脑缩症) 的病例报告.
- 莫达菲尼尔最初是每天100毫克,并定位为每天200毫克,作为增强疗法.
- 在16周内评估了患者的结果,包括情绪,动机,清醒和MADRS分数.
主要成果:
- 患者的情绪,动机和清醒度明显改善.
- 蒙哥马利-阿斯伯格抑郁评分表 (MADRS) 的分数下降了70% (23分),从29分降至6分.
- 在16周的治疗期间,没有观察到任何不良反应或情绪不稳定.
结论:
- 莫达菲尼尔可能是TRBD在老年患者的安全有效的辅助治疗,治疗选择有限.
- 它的良好的耐受性概况表明,在患有TRBD和类似临床挑战的成年人群中具有更广泛的应用潜力.
- 对modafinil在不同成年人群中管理TRBD的作用进行进一步研究是有必要的.
更多相关视频
相关概念视频
01:23Antidepressant Drugs: MAOIs and Other Agents
774
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
774
01:26Psychosis: Goals of Pharmacotherapy
446
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
446
01:15Drug Dosing: Geriatric Patients
212
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
212
01:24Mania and Antimanic Drugs: Overview
530
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
530
01:28Drug Therapy
232
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
232
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
180
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
180