相关实验视频
Updated: Jan 9, 2026

02:22
Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
Published on: April 12, 2024
838
希拉塔综合征的临床表现和管理:一个单中心的经验
Gurusangappa Mudagall1, Uma Kaimal Saikia1, Ashok Krishna Bhuyan1
1Department of Endocrinology, Gauhati Medical College and Hospital, Guwahati, Assam, India.
Journal of the ASEAN Federation of Endocrine Societies
|December 8, 2025
概括
胰岛素自身免疫综合征 (IAS) 是低血糖的一个罕见原因. 通过胰岛素自身抗体检测和管理的早期诊断,包括药物戒断,饮食改变和药物治疗,可以解决症状.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 胰岛素自身免疫综合征 (IAS),也称为Hirata综合征,是一种罕见的内分泌疾病.
- 由于对内源性胰岛素的自身抗体而导致的超胰岛素性低血糖症的特征.
- 由于其稀有性和独特的临床特征,提出了诊断和管理的挑战.
研究的目的:
- 分析IAS的临床表现.
- 评估IAS的诊断方法.
- 根据单一中心的经验,评估IAS的管理策略.
主要方法:
- 在2022年1月至2024年4月期间在第三级护理中心诊断的六名IAS患者的病例系列.
- 对临床病史,药物使用和并发症的审查.
- 低血糖期间的实验室测试 (胰岛素,C-,β-基酸盐,皮质醇),延长的OGTT,72小时的禁食测试和胰岛素自身抗体 (IAA) 测试.
主要成果:
- 确定了六起IAS病例,主要与α-酸和甲基马有关.
- 患有复发性餐后低血糖症的患者.
- 通过胰岛素,C-和IAA水平升高来证实诊断. 治疗包括药物停用,饮食修改和药物治疗 (阿卡尔或普雷迪尼索隆),导致症状消失和IAA水平正常化.
结论:
- 在患有低血糖症的患者和有史以来使用过含硫的药物时,应该怀疑IAS.
- 通过IAA测量和及时管理进行早期诊断对于成功的结果至关重要.
- 进一步的研究是有必要的,以优化IAS治疗和阐明其病原性.
相关概念视频
Gastritis III: Clinical Manifestations and Management
1.1K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.1K
Barrett Esophagus-II: Clinical Manifestations and Management
743
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
743
Nephrotic Syndrome II : Assessment and Medical Management
184
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
184
Cardiomyopathy III: Hypertrophic Cardiomyopathy
374
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
374
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
448
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
448
Gastroesophageal Reflux Disease II: Clinical Features and Management
662
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
662
