血管粘附蛋白-1与心脏动患者主要心血管不良事件之间的相关性
You Zhang1, Chi Geng1, Feng Li1
1Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Frontiers in cardiovascular medicine
|December 8, 2025
概括
血管粘附蛋白-1 (VAP-1) 的升高与患者的心房动 (AF) 发作和主要不良心血管事件 (MACE) 有关. 较高的VAP-1血清水平可能预测AF发病率和预后.
科学领域:
- 心血管研究研究心血管研究
- 生物标志物发现发现
- 炎症研究 炎症研究
背景情况:
- 血管粘附蛋白-1 (VAP-1),一种由炎症诱导的内皮分子,与心血管疾病有关.
- 在心房动 (AF) 中VAP-1的特定作用仍然在很大程度上未被探索.
- 了解VAP-1在AF中的参与对于心血管疾病管理至关重要.
研究的目的:
- 调查血清VAP-1水平与发展AF的风险之间的关联.
- 探索VAP-1在预测AF患者主要心血管不良事件 (MACE) 的预后意义.
- 确定VAP-1作为AF发病率和结果的潜在生物标志物.
主要方法:
- 对356名住院患者的临床数据进行了回顾性分析.
- 使用酶相关免疫吸收试验 (ELISA) 测量血清VAP-1水平.
- 使用回归,曲线拟合和生存分析评估AF发作和MACE.
主要成果:
- 升高的VAP-1水平与AF发作有显著的关联 (HR=1.001).
- 在AF患者中,较高的血清VAP-1水平与MACE风险增加相关 (HR=5.28和HR=28.35).
- 曲线拟合和生存分析证实了回归分析的发现.
结论:
- 在高VAP-1水平和AF发病率和MACE发生之间存在显著的相关性.
- VAP-1成为AF发作的潜在预测生物标志物.
- 血清VAP-1水平可能表明AF和相关心血管事件的预后.
相关概念视频
Intracellular Signaling Affects Focal Adhesions
3.4K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
3.4K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
325
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
325
Atherosclerosis III: Management
296
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
296


