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通过综合转录组分析和机器学习揭示了过敏性鼻炎和亚托皮炎之间的共享诊断基因和潜在机制

Xiaojing Zhang¹, Meng Sun², Liang Xu³

¹Department of Otolaryngology of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Frontiers in allergy

|December 8, 2025

概括

过敏性鼻炎 (AR) 和皮炎 (AD) 具有共同的分子通路. 已发现的五个枢纽基因作为诊断生物标志物和这些相互关联的过敏疾病的潜在治疗点.

科学领域:

免疫学免疫学免疫学
生物信息学是一种生物信息学.
基因组学就是基因组学.

背景情况:

过敏性鼻炎 (AR) 和皮炎 (AD) 经常同时发生.
在AR和AD之间共享的分子机制尚未得到充分理解.

研究的目的:

确定AR和AD的常见诊断生物标志物.
使用生物信息学阐明AR和AD之间的机制联系.

主要方法:

分析了AR和AD患者的转录组数据集.
确定了重叠的差异表达基因 (DEGs).
利用蛋白质-蛋白质相互作用 (PPI) 网络和随机森林建模来找到枢纽基因.

主要成果:

在AR和AD之间发现了36个重叠的DEG.
鉴定了具有强大的诊断价值的五个枢纽基因 (CD274,CYP2E1,FOLH1,SERPINB4,SPRR1B).
发现了参与上皮屏障调节,免疫信号和与特定免疫细胞相关的氧化应激的枢纽基因.

结论:

AR和AD共享一个共同的分子基础.
已识别的五个枢纽基因是诊断的有希望的生物标志物.
这些枢纽基因代表了同时发生的AR和AD的潜在治疗点.

关键词:

过敏性鼻炎过敏性鼻炎亚托邦性皮肤炎的发生.生物标志物生物标志物免疫系统是免疫系统的.这是一个小RNARNA.

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