缺陷构成通过调节瘤免疫微环境,导致清细胞细胞癌的不良结果
Boon Seng Kho1, Zongyuan Zhou2, Rui Liu1
1Department of Traditional Chinese Medicines (TCMs) Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Frontiers in immunology
|December 8, 2025
概括
缺陷宪法 (YDC) 通过改变免疫微环境,影响癌 (ccRCC) 存活率. 这项研究确定了与YDC相关的生物标志物和贝卡莱因作为ccRCC的潜在治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传统中国医学 (TCM) 是一种
背景情况:
- 清细胞细胞癌 (ccRCC) 缺乏早期生物标志物,通常在晚期被诊断出来.
- 传统中医 (TCM) 阳性缺陷宪法 (YDC) 可能通过免疫微环境影响ccRCC.
- YDC和ccRCC预后之间的机制联系尚未得到充分研究.
研究的目的:
- 调查YDC对ccRCC免疫格局和临床结果的影响.
- 根据YDC识别基于ccRCC的新型预后生物标志物和潜在的草药疗法.
- 开发一个YDC指导的ccRCC生物标志物和治疗发现的框架.
主要方法:
- 由YDC分层的ccRCC患者的综合批量和单细胞RNA-seq数据.
- 采用差异表达分析,WGCNA和机器学习来识别生物标志物.
- 利用GSVA和分子对接来选和验证草药剂,专注于免疫调节.
主要成果:
- 与YDC相关的ccRCC患者的生存率较差.
- 一个七基因预后模型 (包括IFNG) 显著影响了ccRCC预后和免疫细胞群 (CD8+ T细胞,Tregs,M1巨细胞).
- 拜卡莱因被确定并验证为一种有前途的治疗向IFNG,用于YDC相关的ccRCC.
结论:
- YDC在ccRCC免疫微环境和患者生存中发挥着关键作用.
- 该研究为ccRCC研究提供了一个新的框架,整合了宪法,免疫力和草药.
- 拜卡莱因在患有YDC的患者中作为ccRCC的潜在辅助疗法出现.
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