在免疫调节和胃肠道癌症免疫治疗中,肠道微生物群衍生代谢物
Wenbin Luo1, Ruoyun Li1, Chaofan Pan1
1The Second Clinical Medical School, Lanzhou University, Lanzhou, China.
Frontiers in immunology
|December 8, 2025
概括
肠道微生物产生SCFA和胆酸等代谢物,影响肠道癌症免疫力和进展. 准这些代谢物为癌症免疫治疗和诊断提供了新的策略.
科学领域:
- 胃肠道瘤学 胃肠道瘤学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物群的代谢物关键地将微生物组成与免疫调节和胃肠道 (GI) 癌症中的瘤进展联系起来.
- 这些代谢物对先天性和适应性免疫,瘤微环境以及炎症/表观遗传通路产生取决于环境的影响.
- 它们的免疫调节作用在全身上超越了肠道.
研究的目的:
- 审查肠道微生物群衍生代谢物的主要类别及其在肠道癌症中的作用.
- 探索这些代谢物如何调节免疫细胞并影响癌症进展.
- 讨论基于代谢物的癌症免疫治疗的新策略和先进平台.
主要方法:
- 对肠道微生物群衍生代谢物在肠道癌症中的文献综述.
- 对代谢物类的分析,包括SCFA,胆酸,托衍生物和新出现的代谢物.
- 讨论具有免疫能力的有机生物共同培养系统,用于评估代谢物作用.
主要成果:
- 酸和乌罗素A可以增强屏障完整性和CD8+T细胞活性,但也可能促进耐受性.
- 胆汁酸具有双重作用;一些促进瘤,而另一些 (例如,UDCA,TUDCA) 抵消促进瘤的胆汁酸.
- 托的代谢产生免疫抑制性 (金氨酸) 和免疫保护性 (英多尔衍生物) 的代谢物,调节T细胞功能.
结论:
- 微生物群衍生代谢物是胃肠道癌症免疫疗法的关键参与者,为精确的诊断和治疗提供了潜力.
- 饮食干预,益生菌和工程微生物可以重塑微生物群-代谢物-免疫轴,以改善免疫治疗结果.
- 具有免疫能力的有机体系统为评估基于代谢物的免疫辅助剂及其与PD-1/PD-L1阻断的组合提供了平台.
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