食物蛋白诱导肠球炎综合征中的口服食品挑战:实用考虑
Rory Nicolaides1, Anna Cheng1, J Andrew Bird1
1From the Department of Pediatrics, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Texas.
Journal of food allergy
|December 8, 2025
概括
诊断食物蛋白诱导肠道炎综合征 (FPIES) 是一个挑战. 口服食品挑战 (OFCs) 是关键的,但时间和方法必须是个性化的,以获得准确的FPIES诊断和管理.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
背景情况:
- 食物蛋白诱导肠道炎综合征 (FPIES) 是一种非IgE介导的食物过敏症,影响所有年龄段,主要是儿童.
- 由于缺乏特定的生物标志物,诊断具有挑战性,依赖于临床病史和口服食品挑战 (OFC).
研究的目的:
- 审查有关诊断儿科FPIES的当前文献.
- 在各种FPIES案件中检查OFC的指示,时间和考虑因素.
- 讨论共同反应性食品的管理和影响OFC设置的因素.
主要方法:
- 关于FPIES诊断和OFC协议的文献审查.
- 分析影响OFC时间,设置和管理策略的因素.
- 检查区域差异和协同反应性食品管理.
主要成果:
- 当符合临床标准并且存在不确定性时,OFC是FPIES的诊断标准.
- 在美国,OFC通常在反应发生12-18个月后进行;时间和触发器患病率存在区域差异.
- OFC的时间和设置取决于食物的重要性,反应严重程度和父母的舒适度;共同反应性食物管理是可变的.
结论:
- 对于FPIES的诊断和管理,需要对OFC的时间和设置采取谨慎的,个性化的方法.
- 根据反应严重程度和食物在饮食中的作用来定制OFC至关重要.
- 为了改善FPIES结果,需要标准化的OFC协议,增强的指导方针和提供者意识.
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