相关实验视频

Updated: Jan 9, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

之前接种疫苗的人群中麻疹血清阳性:系统性审查和元分析

Mohammed Mustafa¹, Alex S Reznik², Juan Uribe¹

¹Department of Internal Medicine, University of Miami, Miami, FL, USA.

EClinicalMedicine

|December 8, 2025

概括

麻疹疫苗的血清阳性在接种疫苗后的十年内仍然很高,但随着时间的推移逐渐减弱. 麻疹抗体的这种下降可能表明免疫力下降,需要进一步研究感染率.

科学领域:

免疫学免疫学免疫学
流行病学流行病学
疫苗学疫苗学疫苗学

背景情况:

麻疹疫情的全球复苏凸显了需要了解疫苗诱导的免疫持续时间.
接种麻疹疫苗后的血清阳性对于评估长期保护至关重要.

研究的目的:

为了测量接种疫苗的个体中麻疹血清阳性患病率.
评估疫苗接种以来麻疹抗体水平随时间变化的情况.

主要方法:

1980年至2025年研究的系统审查和元分析.
包括临床试验,横截面研究,队列研究和病例系列 (≥10名参与者).
超回归以分析与疫苗接种以来的时间相对的血清阳性趋势.

主要成果:

纳入了18项涉及23236名参与者的研究,显示总体血清阳性为87.8%.
随着疫苗接种后的时间,血清阳性下降,每年下降0.48%.
多剂量疫苗接种者的血清阳性 (88.8%) 比单剂量接种者的有限数据 (84.3%) 高.

结论:

在接种疫苗后长达10年的时间内观察到高麻疹血清阳性.
抗体水平的下降表明,随着时间的推移,幽默免疫力可能会下降.
需要进一步的研究,以将血清阳性与实际麻疹感染率相关联.

关键词:

抗体是对抗体的一种.疫苗接种是为了免疫.豁免权是一种豁免权.麻疹是一种麻疹.进行元分析分析.血清阳性是可以证明的.疫苗接种疫苗接种逐渐衰落的衰落的

更多相关视频

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Published on: September 12, 2016

相关概念视频

Vaccinations

Vaccinations

Bias in Epidemiological Studies

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Cross-reactivity

Cross-reactivity