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功能性磁共振成像的应用在识别与脊髓疾病相关的疼痛相关的负责大脑区域

Jing Zhang¹, Nannan Wang², Le-Meng Ren³

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in medicine

|December 8, 2025

概括

休息状态的fMRI揭示了脊髓疾病患者脑活动模式的改变,突出显示了小脑和前额头网络的破坏. 这些发现表明,用于疼痛管理和神经调节的新生物标志物.

科学领域:

神经成像是一种神经成像.
疼痛医学医学疼痛医学
系统神经科学系统神经科学

背景情况:

脊髓疾病的疼痛是一个重大的临床挑战.
目前的治疗方法往往忽视了中枢神经系统的机制.
功能磁共振成像 (fMRI) 为识别中心疼痛点提供了一种潜在的方法.

研究的目的:

使用fMRI检查脊髓疾病相关疼痛患者的静止状态大脑活动.
为了确定患者和对照者之间大脑功能的差异.

主要方法:

对31名脊椎病患者和32名对照患者的回顾性分析.
休息状态fMRI数据采集 (闭眼,清醒).
分析低频波动 (ALFF),区域同质性 (ReHo),功能连接性 (FC) 和中心度 (DC) 的幅度.

主要成果:

在右小脑和上额头回形中增加ALFF;在后中心回形和形中减少ALFF.
在后中心区域 (ReHo) 减少了局部同步.
改变了小脑 - thalamic 和感觉运动网络连接 (FC);改变了小脑和前额连接 (DC).

结论:

休息状态的fMRI揭示了脊柱疾病疼痛中的大脑-丘脑-皮质改变模式.
结果表明小脑参与,前额叶子子专业化和感觉运动干扰.
这些结果可能会指导未来的神经调节研究和用于疼痛管理的生物标志物开发.

关键词:

大脑地图大脑地图大脑重塑的大脑重塑功能性磁共振成像技术功能性磁共振成像技术负责大脑区域负责大脑区域.脊椎疾病与相关的疼痛有关.

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