产前暴露于金属化物混合物和儿童肺功能:探索性别特定的关联
Mayra J Garza1, Cecilia S Alcala2, Marcela Tamayo-Ortiz3
1Department of Perinatal Health, Center for Population Health Research, National Institute of Public Health (INSP), Cuernava, Morelos, Mexico.
Environmental epidemiology (Philadelphia, Pa.)
|December 8, 2025
概括
在第二个三个月内产前暴露于金属混合物与儿童肺功能减弱有关,特别是在女性身上. 这突显了临界暴露窗口和性别特异性的敏感性差异.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 毒理学 毒理学 毒理学
背景情况:
- 产前接触金属化物对儿童健康的担忧越来越大.
- 这些暴露对儿童肺功能的影响,特别是性别特异性的影响,需要进一步研究.
研究的目的:
- 调查产前金属化物暴露对儿童肺功能的性别特异性个人和联合影响.
主要方法:
- 从墨西哥城出生队伍中分析了438个母婴二合体.
- 在怀孕期间测量母亲血液中的金属化物 (As,Cd,Co,Cu,Mn,Ni,Pb,Se,Zn).
- 用多重线性回归,加权量子素和贝叶斯核机器回归评估儿童 (8-14岁) 的肺功能.
主要成果:
- 第二个三个月内 (Ni) 暴露与女性的FEV1/FVC比率较低有关.
- 第三个三个月内 (Co) 和 (Pb) 暴露与女性的FVC和FEV1z-score降低有关.
- 妊娠第二季度总体金属混合物度较高与女性FEV1/FVC和FEF25%-75%的z分数较低有关.
结论:
- 产前接触金属混合物,特别是在怀孕的第二个三个月,与儿童的肺功能下降有关.
- 女性似乎更容易受到产前金属化物暴露对肺部发育的不良影响.
- 了解关键暴露窗口和性别差异对于降低风险至关重要.
相关概念视频
Types of Toxins
3.1K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.1K
The Periodic Table and Organismal Elements
22.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
22.1K


