产前野火烟雾暴露和早产表型:一个回顾性队列研究
Anne R Waldrop1, Yair J Blumenfeld1, Jonathan A Mayo1
1Division of Maternal Fetal Medicine & Obstetrics, Department of Obstetrics & Gynecology, Stanford University, Stanford, California.
野火烟雾暴露与早产 (PTB),特别是自发性PTB (sPTB) 有关. 这种关联在各种妊娠期中观察到,突出显示了烟雾对怀孕结果的影响.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 公共卫生 公共卫生
背景情况:
- 新出现的证据表明,野火烟雾暴露与早产 (PTB) 之间存在联系.
- 这种关联的确切机制和关键暴露窗口仍然不清楚.
- 了解这些因素对于公共卫生干预至关重要.
研究的目的:
- 调查野火烟雾暴露与特定的早产现象型之间的关联:自发性PTB (sPTB) 和医学上指示的PTB (mPTB).
- 为了检查野火烟雾暴露和妊娠高血压障碍 (HDP) 之间的关系.
- 为了确定怀孕期间与不良分娩结果相关的关键暴露时间.
主要方法:
- 利用加利福尼亚州出生队列数据 (2007-2012) 进行单人活产.
- 综合每日野火烟雾强度估计 (PM2.5度) 在邮政编码层面.
- 使用逻辑回归模型评估从怀孕前4周到怀孕第20周的暴露.
主要成果:
- 在250万例新生儿中,有86%暴露于野火烟雾中.
- 野火烟雾暴露与sPTB (OR 1.003,95% CI [1.0021,1.0039]) 有着显著的关联,每增加一天,sPTB的几率都会增加0.3%.
- 在14-20周的烟雾暴露和mPTB之间发现了相关性 (OR 1.0038,95%CI [1.0008,1.0069]). 没有观察到与HDP的显著联系.
结论:
- 野火烟雾暴露与早产风险增加有关,主要是由自发性PTB驱动的.
- 特定的妊娠窗口,特别是14-20周,显示与医学上适用的PTB相关.
- 这些发现强调了野火烟雾对怀孕和分娩结果的公共卫生影响.
更多相关视频
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
相关概念视频
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Asthma-I: Introduction
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
