在儿童和青少年中霍奇金淋巴瘤的全球负担:使用GBD 2021的基于人口的研究
Jie Chen1, Yue Wang1, Jindou Guo2
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China.
Frontiers in pediatrics
|December 8, 2025
概括
在全球范围内,儿童和青少年的霍奇金淋巴瘤 (HL) 负担正在增加,特别是在低收入国家. 解决健康不平等问题对于改善结果和实现全球儿童健康目标至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 流行病学 流行病学
- 全球健康 全球健康
背景情况:
- 霍奇金淋巴瘤 (HL) 是一种罕见但显著的恶性瘤,影响儿童和青少年.
- 在高收入地区,死亡率正在下降,但由于资源有限,在低收入和中等收入国家仍然很高.
研究的目的:
- 从1990年到2021年,分析霍奇金淋巴瘤在儿童和青少年中的全球负担.
- 评估不同社会人口指数 (SDI) 的发病率,死亡率和残疾调整寿命年 (DALYs) 的趋势.
- 预测未来的疾病负担,并确定差异.
主要方法:
- 利用了2021年全球疾病负担研究 (GBD) 的数据.
- 雇佣年龄期队列 (APC) 和Nordpred模型用于趋势分析和未来预测.
- 应用结点回归来识别疾病趋势的显著时间变化.
主要成果:
- 在2021年,HL占到了265,016个DALY,全球有8,700例新增病例和3,385例死亡.
- 从1990年到2021年,年龄标准化发病率 (ASIR) 全球下降9.52%,但病例数量增加.
- 不平等仍然存在,低收入和中等收入地区的高收入负担越来越大,与高收入地区的下降趋势形成鲜明对比. 男性不成比例地受到影响.
结论:
- 在儿童和青少年中,霍奇金淋巴瘤的负担呈现出日益增长的趋势,根据性别和地区存在显著差异.
- 迫切需要在缺乏资源的环境中提供公平的诊断和治疗,以实现可持续发展目标的目标.
- 解决健康不平等问题对于改善与霍奇金淋巴瘤相关的全球儿童健康结果至关重要.
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