与格雷夫斯病和肝功能障碍相关的可逆损伤综合征:一个病例报告
Xingchen He1, Yijia Lin1, Jing Chen1
1Department of Neurology, The Affiliated Guangzhou Hospital of TCM of Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in neuroscience
|December 8, 2025
概括
可逆损伤综合征 (RESLES) 可能导致精神症状. 这个案子突出了格雷夫斯的存在.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 可逆损伤综合征 (RESLES) 是一种罕见的疾病,引起严重的精神症状,原因不明,通常与细胞毒性脑有关.
- 感染,发作,代谢障碍和超大胞性脑可能引发RESLES.
- 这项研究侧重于与格雷夫斯病和肝功能障碍相关的RESLES病例.
研究的目的:
- 报告一个独特的RESLES病例,该病例发生在一位同时患有Graves病和肝功能障碍的患者身上.
- 在这个特定的患者档案中调查RESLES的潜在触发因素和临床特征.
- 为了解RESLES病因和管理做出贡献.
主要方法:
- 一个17岁的女青少年出现神经和精神症状的案例报告.
- 诊断工作包括磁共振成像 (MRI) 用于RESLES诊断.
- 实验室测试评估了甲状腺功能 (FT3,FT4,TSH,TRAb) 和肝功能 (ALT,AST).
主要成果:
- 患者表现出与RESLES一致的症状,格雷夫斯病 (FT3/FT4升高,TSH低,TRAb阳性) 和肝功能障碍 (ALT/AST升高).
- 用抗甲状腺药物 (甲基马) 和激素疗法 (甲基普雷迪尼索隆糖酸盐) 治疗导致症状消失.
- 随访MRI显示脑成像正常化.
结论:
- 格雷夫斯病是一种自身免疫性甲状腺功能障碍的形式,可能是RESLES的新触发因素.
- 该患者对特定的抗甲状腺和激素疗法表现出敏感性,导致预后有利.
- 在RESLES病例中同时出现的肝功能障碍需要进一步调查,以了解其作用和影响.
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