研究Changmaxifeng颗粒的药物物质和作用机制,以对抗提克障碍
Li-Dong Xie1, Jian-Ping Wu1, Shu-Sen Liu1
1School of Pharmacy, Harbin University of Commerce, Harbin 150076, Heilongjiang Province, China.
World journal of psychiatry
|December 8, 2025
概括
长马西峰颗粒 (CG) 含有各种化学成分,显示出治疗障碍 (TDs) 的治疗潜力. 这项研究确定了关键活性化合物及其机制,为未来的临床应用提供了基础.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
- 系统生物学 系统生物学
背景情况:
- 障碍 (TDs) 是一种神经和精神疾病,涉及非自愿的声音或运动.
- 长马颗粒 (CG) 已在治疗TD中表现出临床疗效,但其活性成分和机制在很大程度上仍未知.
研究的目的:
- 为了确定CG中负责治疗TD的药物物质.
- 使用综合方法阐明CG对TD的行动机制.
主要方法:
- 血清药物化学,包括超高性能液体染色学-四极飞行时间质谱学 (UHPLC-QTOF-MS),以确定血液中吸收的成分.
- 网络药理学分析复合疾病向相互作用和蛋白质-蛋白质相互作用 (PPI) 网络.
- 分子对接,基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 途径分析以确定机制.
主要成果:
- 在体外发现了187个和体内发现了75个CG的化学成分,包括类,黄类和代谢物.
- 发现了225个重叠的目标,其中TNF,IL-6,FOS,VEGFA和ESR1被确定为关键目标.
- 确定了乙醇,埃沃林B,阿斯帕拉丁和乙作为潜在的活性化合物,对核心标具有强烈的结合亲和力.
结论:
- 这项研究成功地确定了CG的体外和体内化学成分.
- 这项研究概述了CG对动障碍的潜在治疗目标和作用机制.
- 为进一步研究和临床应用CG在治疗TD提供了科学基础.
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