母亲因素导致肠道微生物群和胃肠功能在自闭症谱系障碍中的变化
1China Academy of Chinese Medical Sciences, Institute of Acupuncture and Moxibustion, Beijing 100000, China. wxxcacms@163.com.
World journal of psychiatry
|December 8, 2025
概括
怀孕期间母亲的健康显著影响后代.
科学领域:
- 神经发育障碍 神经发育障碍
- 孕产妇健康 孕产妇健康
- 胃肠道的健康状况
背景情况:
- 自闭症谱系障碍 (ASD) 是一种由遗传和环境因素影响的神经发育状况.
- 怀孕期间母亲的健康是子女神经系统发育的关键因素.
- 母亲的健康状况不佳可能会改变后代的神经系统的发育,包括中枢神经系统 (CNS) 和肠道神经系统 (ENS),以及微生物群的组成.
研究的目的:
- 审查母亲健康状况对后代胃肠道和精神系统发育的影响.
- 提高公众对母亲健康在神经发育中的重要性的认识.
- 为孕前健康和生育策略提供见解.
主要方法:
- 文献综述,重点关注母亲健康及其对后代神经发育的影响.
- 分析母亲健康,肠道健康和后代中枢神经系统发育之间的关系.
- 从母亲健康在ASD病因学中的作用的角度进行讨论.
主要成果:
- 母亲的健康状况极大地影响着后代中枢神经系统和内枢神经系统的发展.
- 不利的孕产妇健康状况可能导致神经系统发育的中断和微生物群的变化.
- 将母亲健康状况不佳与ASD相关的中枢神经系统和肠神经系统变化联系在一起的确切机制需要进一步研究.
结论:
- 母亲的健康是后代神经发育结果的重要决定因素,包括患ASD等疾病的风险.
- 了解这些联系可以为改善生育和早期发育的战略提供信息.
- 需要进一步的研究来阐明母亲健康影响后代神经系统的具体途径.
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