一种新型的超声波水可以缓解便秘,并具有良好的安全性
Jiarong Hu1, Xinyi Hu1, Wenjie Huang1,2
1School of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Fudan University, Shanghai, China.
Frontiers in toxicology
|December 8, 2025
概括
超声波水 (UW) 通过影响胃肠道激素,有效地缓解了老鼠的便秘. 综合的安全评估证实UW是无毒的,没有变种效应,表明其作为安全功能饮料的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
- 功能性食品 功能性食品
背景情况:
- 便秘是一种普遍的胃肠道疾病,影响着全世界数以百万计的人.
- 功能饮用水是健康促进饮料的一个新兴类别.
- 超声波水 (UW) 是一种具有潜在治疗应用的新型功能水.
研究的目的:
- 评估超声波水 (UW) 在便的老鼠模型中的药效果.
- 通过检查胃肠道激素水平来研究UW的药作用的潜在机制.
- 通过各种毒理学测试,对UW进行全面的安全评估.
主要方法:
- 在Sprague-Dawley (SD) 老鼠中诱导了一种便秘模型,以评估UW的净化作用.
- 安全性通过急性和亚急性口服毒性测试,艾姆斯测试和微核测试来评估.
- 胃肠道激素的血清水平 (莫提林,物质P,VIP,ACHE,体静止素) 被量化.
主要成果:
- 与模型组相比,UW显著改善了试验大鼠的便秘症状和体重增加.
- 激发性胃肠道激素 (莫提林,物质P,VIP,ACHE) 的血清水平增加,而体静止素则下降.
- 紫外线显示出高急性口服毒性 (LD50> 20000 mg/kg),在亚急性测试中没有副作用,并且没有变种或基因毒性潜力.
结论:
- 超声波水在老鼠便秘模型中表现出显著的松作用.
- 紫外线的净化作用与关键胃肠道激素的调节有关.
- UW拥有有利的安全概况,支持其作为安全功能饮用水的潜力.
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