跨物种的皮层几何学揭示了灵长类动物和人类特异性扩张之间的保存梯度.
Yifan Wei1, Yufan Wang2,3, Tingwei Wei1
1School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China.
bioRxiv : the preprint server for biology
|December 8, 2025
概括
灵长类动物的大脑进化表明,皮质几何结构保留,但关联区域不同. 人类皮层几何学与基因活动联系在一起,揭示了对大脑发育和进化的洞察力.
科学领域:
- 神经科学是一个神经科学.
- 比较解剖学的比较.
- 进化生物学 进化生物学
背景情况:
- 灵长类大脑皮层的复杂几何结构支持先进的认知,区分灵长类.
- 跨物种的皮质几何图案及其与人类转录架构的联系尚未得到充分理解.
研究的目的:
- 调查灵长类皮层几何学,结构连接和扩张的跨物种相似性和差异.
- 探索人类皮层几何学的转录基础.
主要方法:
- 开发了一个基于几何学的跨物种皮层对齐框架.
- 分析了,黑猩猩和人类的结构连接和皮层扩张.
- 在人类皮层几何学上进行了神经图像转录分析.
主要成果:
- 识别了物种间皮层几何特征的保存空间模式.
- 在感官/体力运动区域中发现了高的结构连接相似性,但在关联皮层中存在分歧.
- 在默认模式网络中观察到不成比例的皮层扩张,以及几何和神经发育/连接基因之间的相关性.
结论:
- 灵长类动物的大脑皮层表现出一种保存的,但在层次上差异化的组织.
- 这些发现为人类大脑进化及其遗传结构的生物学基础提供了新的见解.
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