在泡柱生物反应器中切割率分布的CFD建模:泡直径和升力力的影响
Ana Carolina B Silva1,2, Mateus N Esperança3, Alberto C Badino1
1Department of Chemical Engineering, Federal University of São Carlos, Rod Washington Luis, São Carlos, SP, Postal Code 13565-905, Brazil.
ACS omega
|December 8, 2025
概括
计算流体动力学 (CFD) 模拟显示,提升力显著影响气泡柱生物反应器中的剪切速率. 最大切割速率 (max) 成为优化生物反应器设计的优质指标.
科学领域:
- 生物技术是生物技术.
- 化学工程是化学工程的重要组成部分.
- 流体动力学 流体动力学
背景情况:
- 剪切速率 (
γ̇ ) 对于生物反应器性能评估至关重要. - 平均剪切率 (平均剪切率) 传统上用于比较生物反应器设计.
- 微生物形态和生存能力受到剪切环境的影响.
研究的目的:
- 为了研究提升力对气泡柱生物反应堆最大 (
) 和平均 (γ̇ max ) 剪切速率的影响.γ̇ a v - 为了评估气泡直径变化的影响切割速率,当考虑提升力时.
- 为生物反应器性能比较提出一个改进的指标.
主要方法:
- 利用计算流体动力学 (CFD) 采用双流体欧利尔模型进行气液多相模拟.
- 模拟了一系列特定的空气流速 (1-5vm) 和不同的平均气泡直径.
- 分析了局部速度梯度及其对剪切速率的影响.
主要成果:
- 提升力显著放大了气泡直径对局部速度梯度的影响.
- 剪切速率 ( 和
- 最大切割速率 (max) 显示了对这些变化的更大的敏感性.
结论:
- 最大切割速率 () 可能是一个比平均切割速率 () 更有效的指标来比较生物反应器的性能.
- 将提升力纳入CFD模拟中,可以更准确地评估剪切环境.
- 这些发现为优化生物技术系统设计提供了一个框架.
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