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用益生菌补充治疗儿科腹管理:随机对照试验的结果
Shaojie Liang1, Liujing Huang2, Kai Ma3
1Shunde Women and Children's Hospital of Guangdong Medical University (Maternity and Child Healthcare Hospital of Shunde Foshan), Foshan, China.
像Limosilactobacillus reuteri和Bifidobacterium breve这样的益生菌补充剂可以帮助恢复腹的儿童的肠道细菌,特别是在服用抗生素时. 然而,与安慰剂相比,它们没有显著缩短腹持续时间或改善症状.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 腹是一种重要的儿科疾病.
- 益生菌正在作为儿童腹的辅助治疗方法进行研究.
- 肠道微生物群在健康和疾病中起着至关重要的作用.
研究的目的:
- 评估Limosilactobacillus reuteri FPHC2951和Bifidobacterium breve FPHC4024对腹儿童肠道微生物群组成的影响.
- 评估益生菌是否提供超出小儿腹标准护理的额外临床益处.
主要方法:
- 一个随机,双盲,安慰剂控制的试验,涉及141名儿童 (6个月至6岁).
- 干预组接受了特定的益生菌菌株或安慰剂一个月的标准护理.
- 在干预前后使用16S rRNA基因测序分析了肠道微生物群.
主要成果:
- 所有组都显示微生物α多样性的增加.
- 益生菌组表现出更多的Limosilactobacillus和Bifidobacterium的丰富.
- 在所有组中,Clostridioides difficile水平都下降了.
- 在接受抗生素的儿童中,益生菌组中的微生物群变化更为明显.
- 两组之间没有观察到腹持续时间或临床症状的显著差异.
结论:
- 益生菌补充剂有助于在儿科腹和抗生素治疗期间恢复肠道微生物组成.
- 这些益生菌在治疗腹症状的标准治疗中所带来的额外临床益处目前有限.
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