年轻人与物质使用障碍的遗传责任相关
Sarah E Paul1, Aaron J Gorelik1, Nicole R Karcher2
1Psychological & Brain Sciences, Washington University in Saint Louis, Saint Louis, Missouri.
medRxiv : the preprint server for health sciences
|December 8, 2025
概括
对物质使用障碍 (SUDs) 的遗传倾向出现在童年,而不仅仅是青春期. 早期识别这些风险因素,如心理健康和睡眠问题,可能有助于预防未来的成.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
背景情况:
- 药物使用障碍 (SUD) 是遗传性的,在青春期/年轻成年期出现.
- SUD相关性 (倾向与后果) 的起源尚未完全理解.
研究的目的:
- 调查儿童中SUDs早期遗传基础.
- 为了确定与SUD多基因风险得分 (PRS) 相关的表型关联,在青春期前.
主要方法:
- 通过使用青少年大脑认知发展 (ABCD) 研究的数据进行了一项全现象关联研究 (PheWAS).
- 分析了各种SUD (问题性酒精使用,烟草使用障碍,大麻使用障碍,阿片类药物使用障碍,成风险因素) 的多基因风险评分.
- 检查了与心理健康,睡眠,屏幕时间和咖啡因消费表型的关联.
主要成果:
- 在8至13岁的儿童中确定了309种与SUD PRS的表型关联.
- 大多数关联在尚未接触到物质的参与者中被发现.
- 神经成像数据部分解释了SUD PRS和屏幕时间之间的联系.
结论:
- 对SUDs的遗传责任在童年时表现为潜在可修改的风险因素.
- 早期识别和针对这些儿童现象型的干预可以缓解后来的SUD发展.
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