低频 BOLD 振荡,APOE4 和等离子体 pTau 的217
Trevor Lohman1,2, Arunima Kapoor3, Allison C Engstrom3
1Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
medRxiv : the preprint server for health sciences
|December 8, 2025
概括
大脑信号的低频振荡与APOE4载体的阿尔茨海默病风险有关. 下脑振荡与较高的pTau217水平相关,这表明早期的疾病参与.
科学领域:
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 血液氧气水平依赖的低频振荡 (BOLD-LFO) 在大脑连接分析中经常被忽视.
- 新出现的证据表明,BOLD-LFO可能表明大脑血管功能障碍和早期阿尔茨海默病 (AD) 病理生理学.
- 将BOLD-LFO与AD联系在一起的精确机制以及它们与等离子pTau217的关联,特别是在APOE4载体中,仍然未被探索.
研究的目的:
- 为了研究BOLD-LFO与血pTau217水平之间的关系.
- 为了确定这种关系是否受到阿波利波蛋白-e4 (APOE4) 载体状态的改变.
- 根据APOE4和粉样β (Aβ) 阳性,探索BOLD-LFO的差异.
主要方法:
- 招募了118名独立生活的老年人,没有主要的神经或精神疾病.
- 获得的静止状态功能性MRI和血液样本用于血pTau217评估.
- 量化了BOLD-LFO,并使用线性回归和ANCOVA分析了APOE4状态和BOLD-LFO对pTau217的相互作用效应.
主要成果:
- 与血pTau217 (β=-.65, p=.004) 相关的是APOE4载体状态和BOLD-LFO功率之间的显著相互作用.
- 在APOE4载体 (β=-.49,p=.003) 中观察到BOLD-LFO和血pTau217之间的反向关系.
- 与非携带者和非携带者相比,粉样β阳性APOE4携带者表现出较低的BOLD-LFO.
结论:
- 大胆的LFO涉及到早期的AD病理生理学,以一种依赖APOE4的方式.
- 这些发现支持对BOLD-LFO关于大脑血管对AD遗传风险的贡献的进一步调查.
- 这项研究强调了BOLD-LFO作为AD研究中的生物标志物的潜力.
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