校正: 一种Ganoderma atrum的多糖减轻了DSS诱导的性结肠炎,通过保护亡/自调节的物理屏障和DC相关的免疫屏障
Bing Zheng1, Mengxi Ying1, Jianhua Xie1
1State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China. yuqiang8612@163.com.
Food & function
|December 8, 2025
概括
发现一个Ganoderma atrum多糖化合物可以缓解DSS诱导的性结肠炎. 它通过保护物理屏障和树突细胞相关的免疫屏障来实现这一目标,调节亡和自.
科学领域:
- * 食品科学与技术 * 食品科学与技术
- * 免疫学 免疫学
- * 胃肠病学 胃肠病学
背景情况:
- * 性结肠炎 (UC) 是一种慢性炎症性肠病.
- * 物理屏障和免疫反应在UC病变发生过程中至关重要.
- *自然化合物正在UC中探索其治疗潜力.
研究的目的:
- * 为了研究Ganoderma atrum多糖 (GAP) 对DSS诱导的性结肠炎的治疗作用.
- *阐明GAP的保护作用背后的机制,重点关注亡,自,物理屏障完整性和树突细胞 (DC) 功能.
主要方法:
- * 在动物中建立DSS诱导的性结肠炎模型.
- * 用Ganoderma atrum多糖的药物.
- *评估结肠组织学,屏障功能标记物,亡/自相关蛋白质以及DC群体和功能.
主要成果:
- *GAP治疗显著缓解了DSS诱导的结肠炎症和组织损伤.
- * GAP通过调节亡和自来保护肠道物理屏障.
- * GAP调节树突细胞功能,有助于免疫恒常.
结论:
- * 牛的多糖体显示出对性结肠炎的显著治疗潜力.
- * 它的保护作用包括物理屏障和DC相关的免疫屏障的双重调节.
- * GAP代表了对炎症性肠道疾病的有前途的天然治疗剂.
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