门德尔随机化分析支持精神疾病与尿路感染风险之间的因果关系.
Minghui Ke1, Haolang Wen2,3, Binghao Bao1
1Department of Andrology, China-Japan Friendship Hospital, Beijing, China.
American journal of men's health
|December 8, 2025
概括
这项研究发现,主要抑郁症 (MDD) 和自闭症谱系障碍 (ASD) 因果上会增加尿路感染 (UTI) 的风险. 尿路感染也稍微增加了MDD风险,吸烟中介于MDD-UTI联系.
科学领域:
- 精神病学基因组学 精神病学基因学
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 观察性研究表明,尿路感染和精神疾病之间存在联系.
- 这种并发症的因果性仍然不清楚,需要进行严格的调查.
研究的目的:
- 调查主要精神疾病和尿路感染之间的双向因果关系.
- 确定心理健康状况与尿道感染之间的关联中的潜在调解因素.
主要方法:
- 使用双向门德尔随机化 (MR) 分析,使用来自精神病基因组学联盟和英国生物银行的大规模遗传数据.
- 采用多变量门德尔随机化 (MVMR) 来调整混因素并评估独立效应.
- 应用逆方差加权 (IVW) 和其他MR方法来估计因果关系.
主要成果:
- 对主要抑郁症 (MDD) 和自闭症谱系障碍 (ASD) 的遗传责任显著增加了尿路感染风险 (分别为1.31和1.08).
- 尿路感染与MDD风险的适度增加有关 (OR 1.061).
- 多变量MR证实了MDD对尿路感染风险的因果作用 (OR 1.25),吸烟调解了这一关联的13.6%.
结论:
- 确立了特定精神疾病,特别是MDD和ASD,和尿路感染风险增加之间的因果关系.
- 确定吸烟是MDD和尿路感染之间的因果途径的重要调解者.
- 这些发现支持综合临床方法,用于管理伴随性精神健康和尿路疾病的患者.
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