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Updated: Jan 9, 2026

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基因组下一代测序诊断塔拉罗米切斯马内菲感染:病例报告和综述

Shu Xu¹, Yi Ding², Mengshuo Li³

¹Department of Respiratory Medicine, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital, Nanjing Medical University, 215 Guangzhou Road, Nanjing, 210029, China.

Journal of infection in developing countries

|December 8, 2025

概括

塔拉罗米切斯马尔内菲感染越来越多地出现在特有地区以外的非免疫受损个体中. 下一代元基因组测序 (mNGS) 在这些具有挑战性的情况下有助于诊断.

科学领域:

医学真菌学医学真菌学
传染性疾病传染性疾病
诊断微生物学诊断微生物学

背景情况:

塔拉罗米塞斯马尔内菲 (Talaromyces marneffei) 是一种二形真菌,会引起严重的机会性感染.
地方性地区主要是东南亚和中国南部.
感染通常与艾滋病毒或抗IFN-γ抗体阳性有关.

研究的目的:

在流行地区以外的非艾滋病毒患者中报告Talaromyces marneffei感染病例.
突出诊断挑战和mNGS的实用性.
提高医生对非流行性,非艾滋病毒患者群体的塔拉罗米科斯的认识.

主要方法:

一个年轻的男性患者的病例报告.
最初的错误诊断是结核病.
通过元基因组下一代测序 (mNGS) 证实了诊断.

主要成果:

患者居住在流行地区之外,没有艾滋病毒,出现了持续的咳和唾液.
最初的抗结核治疗是无效的.
下一代元基因组测序 (mNGS) 已经成功识别出Talaromyces marneffei.
用脂质体安波特里辛B治疗导致临床改善.

结论:

在非免疫抑制个体中,Talaromyces marneffei感染正在出现.
由于误诊,延迟诊断是很常见的.
mNGS是检测T. marneffei在非特有地区的宝贵工具.
提高医生意识对于及时诊断和治疗至关重要.

关键词:

案例报告案例报告抗IFN-γ的自身抗体.肺肺肺肺肺肺肺肺肺基因组下一代测序的测序.皮肤卷入皮肤卷入塔拉罗米科西斯是一种发病性疾病.

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