在叙利亚患者中,社区获得的致肺炎细菌和抗生素耐药率
Rana Habeeb1, Kenda Jawich1, Lana Charaf1
1Department of Biology and Medical Sciences, Faculty of Pharmacy, International University of Science and Technology, Damascus, Syria.
抗菌素耐药性是叙利亚社区获得性肺炎 (CAP) 治疗的主要威胁. 当地数据显示,细菌对常见抗生素具有很高的耐药性,因此需要量身定制的治疗策略.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球卫生问题,显著增加了社区获得性肺炎 (CAP) 的感染和死亡率.
- 发展中国家,如叙利亚,由于资源和基础设施有限,在打击抗药性耐药性方面面临着特殊的挑战.
研究的目的:
- 为了确定在叙利亚大马士革引起CAP的细菌的流行率.
- 评估这些细菌的抗生素耐药性模式.
- 为CAP提供当地处理指南.
主要方法:
- 在叙利亚大马士革的Ibn Al-Nafis医院进行了一项横截面研究.
- 在2022年9月至2023年3月期间,对100名患有CAP的患者进行了采样.
- 进行了细菌鉴定和抗生素敏感性测试.
主要成果:
- 肺炎性链球菌 (41%),金黄色葡萄球菌 (16%) 和Klebsiella sp. 这三种菌. (14%) 是最常见的CAP病原体.
- 对于通常推的抗生素,包括阿莫西西林 (>80%),观察到高耐药率.
- 格拉姆阴性细菌表现出比格拉姆阳性细菌更高的耐药性,对酸黄有100%的耐药性.
结论:
- 当地抗生素耐药性数据对于适应全球治疗指南 (例如,世卫组织) 至关重要.
- 持续的本地监测,设备齐全的实验室和传染病专家对于有效的农业政策管理至关重要.
- 根据局部耐药性模式量身定制经验性抗生素治疗对于改善患者的治疗结果至关重要.
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