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在乙型肝炎和型肝炎感染人口中细胞巨乳病毒的重新激活

Ivana Talić Drlje¹, Božo Šušak¹, Jurica Arapović¹

¹University of Mostar, School of Medicine, Mostar, BA, Bosnia and Herzegovina.

Journal of infection in developing countries

|December 8, 2025

概括

在波斯尼亚和黑塞哥维那,细胞巨乳病毒 (CMV) 血清流行率很高. 这项研究发现,与对照人群相比,B型肝炎 (HBV) 或C型肝炎 (HCV) 患者的CMV活性没有增加.

科学领域:

病毒学病毒学
肝病学肝病学是一种肝病学.
传染性疾病传染性疾病

背景情况:

细胞巨乳病毒 (CMV) 血清流行率呈现全球变异.
了解CMV血清流行和活性化是至关重要的,特别是在感染B型肝炎病毒 (HBV) 或C型肝炎病毒 (HCV) 的人群中.

研究的目的:

为了确定细胞巨乳病毒 (CMV) 血清流行率和活性化率.
调查乙型肝炎 (HBV) 或乙型肝炎C (HCV) 患者和对照组之间的CMV再激活的潜在差异.

主要方法:

一项涉及264名成年参与者的研究,包括63名B型肝炎患者 (HBV),69名C型肝炎患者 (HCV) 和132名对照患者,该研究于2017年至2022年期间进行.
测量所有参与者的CMV IgG和IgM水平;对那些阳性于CMV IgG和IgM的人进行CMV IgG激烈性测试.

主要成果:

总体CMVIgG血清流行率为95.4%,HCV阳性 (98.5%),HBV阳性 (96.8%) 和对照 (95.2%) 组的高发病率.
在抗HCV阳性受访者中,总体CMV再激活率为2.9%,在可检测HCVRNA的个人中观察到的更高率 (4.4%). 在HBV组中没有检测到CMV再激活.
在抗HCV阳性和阴性受访者之间,或在HBV/HCV阳性个人和对照者之间,没有发现CMV活性率的显著差异.

结论:

与对照组相比,该研究没有证实HBV或HCV阳性患者的CMV活性率升高.
波斯尼亚和黑塞哥维那的高CMV血清流行需要进一步的研究.
未来的研究应该包括CMVDNA测试,以便更精确地评估活性化.

关键词:

在CMV中使用CMV.这就是HBV HBV.在HCV病毒感染的过程中,流行病学流行病学再激活重新激活的方法

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