隐藏的调节者:KMT2A重排的急性淋巴细胞白血病中的非编码RNA
Maria Augusta Poersch1, Ana Carolina Rodrigues1, Priscila Elias Ferreira Stricker1
1Genetics Post-Graduation Program, Genetics Department, Federal University of Parana, Curitiba, Parana, Brazil.
International journal of cancer
|December 8, 2025
概括
非编码RNAs (ncRNAs) 在KMT2A重组的婴儿急性淋巴细胞白血病 (ALL) 中发挥着关键作用. 这些分子影响基因表达和表观遗传调节,具有作为生物标志物和治疗点的潜力.
科学领域:
- 血液瘤学 血液瘤学
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 由于KMT2A的重组,导致了婴儿急性淋巴细胞白血病 (ALL) 的侵袭性发展.
- 非编码RNAs (ncRNAs) 正在成为KMT2A-r ALL中的关键调节者.
- ncRNAs影响基因表达,染色体动态和表观遗传景观.
研究的目的:
- 阐明 ncRNAs 在 KMT2A-r ALL 发病过程中的多方面的作用.
- 探索ncRNAs作为生物标记物和治疗点的潜力.
主要方法:
- 关于KMT2A-r ALL中ncRNAs的当前文献的综述.
- 分析各种ncRNA类 (circRNAs, lncRNAs, miRNAs, eRNAs) 的功能影响.
主要成果:
- 循环RNAs (circRNAs) 导致基因组不稳定性和化学抵抗性.
- 长非编码RNA (lncRNAs) 保持了白血病干细胞的特性.
- 微RNAs (miRNAs) 和增强型RNAs (eRNAs) 调节致癌网络和基因表达.
结论:
- ncRNAs是KMT2A-r ALL调节电路的组成部分.
- ncRNAs显示出作为生物标志物对分类,风险分层和治疗反应的承诺.
- 向ncRNAs为高风险ALL的精准医学提供了治疗机会.
更多相关视频
09:52A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
Published on: December 4, 2018
7.9K
07:24Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
6.8K
相关概念视频
02:23Master Transcription Regulators
7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
02:39lncRNA - Long Non-coding RNAs
9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
03:18Non-LTR Retrotransposons
13.1K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.1K
02:04Co-activators and Co-repressors
8.3K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.3K
02:23Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
01:15Receptor Downregulation in MVBs
2.7K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.7K