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血大麻素度和转移在牛长期工业大麻管理期间

Bailey R Fritz¹, Michael D Kleinhenz², Jason J Griffin³

¹Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506.

Journal of animal science

|December 8, 2025

概括

牛中的工业大麻 (IH) 需要了解大麻素的药理动力学. CBD-7-酸可能表明IH暴露,但由于潜在的交叉污染和未暴露牛中的检测,需要进一步测试.

科学领域:

兽医药理学兽医药理学
食品安全食品安全
牲畜中的大麻素代谢

背景情况:

在牛中增加工业大麻 (IH) 的使用需要了解大麻素的药理动力学.
对进入食品供应的牛产品制定安全指南至关重要.
以前的研究描述了大牛中的大麻酸 (CBDA) 药理动力学.

研究的目的:

为了评估荷尔斯坦牛的血大麻素度,牛被食不同饮食.
为了评估工业大麻管理后的大麻素的药理学特征.
为在食品动物中进行大麻素测试的监测计划提供信息.

主要方法:

十二只霍尔斯坦牛被分配到安慰剂,甲素 (CTC),IH或CTC + IH组63天.
血样本每周从第7天到第77天收集一次.
量化了11种大麻素,重点关注的是 (-) -7-nor-7-carboxy cannabidiol (CBD-7-酸).

主要成果:

CBD-7-酸达到最高的血度,并且比其他大麻素持续时间更长.
在未给予IH的牛中检测到CBD-7酸,这表明潜在的交叉暴露或环境污染.
9-THC,THCA和CBDA被检测得很少,可能是由于样品污染.

结论:

CBD-7-酸显示出作为牛IH暴露的查标志物的潜力.
由于CBD-7酸存在于未暴露群体中,因此需要进行确认性测试或特定的解释标准.
这些发现对于制定监测策略和为食用动物产品中的大麻素设定容忍值至关重要.

关键词:

大麻素是一种大麻素.这里是牛群.风险暴露风险暴露风险暴露工业大麻是一种工业大麻.血等离子体是什么?转移的转移方式

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