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相关概念视频

Phylogeny01:23

Phylogeny

56.6K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
56.6K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Phylogenetic Trees03:21

Phylogenetic Trees

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Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
49.1K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
548
Synteny and Evolution02:31

Synteny and Evolution

3.7K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
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相关实验视频

Updated: Jan 9, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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eggNOG v7:基于系系的正统学预测和功能注释.

Ana Hernández-Plaza1, Ziqi Deng1, Fabian Robledo-Yagüe2

  • 1Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Campus de Montegancedo-UPM, 28223 Madrid, Spain.

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概括

eggNOG v7数据库增强了进化基因分析,提供了一个新的基因组学,以域为中心的工作流. 这种基因组资源改善了数百万种蛋白质的正统组重建和功能注释准确性.

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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
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A Practical Guide to Phylogenetics for Nonexperts

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相关实验视频

Last Updated: Jan 9, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
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科学领域:

  • 基因组学就是基因组学.
  • 进化生物学 进化生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • eggNOG数据库提供了对不同物种的ortology推断和功能注释.
  • 之前的版本在正统组重建中面临着计算和准确性限制.

研究的目的:

  • 为了介绍eggNOG v7,它采用了一种新的基因组学,以域为中心的工作流.
  • 为了增强正义组 (OG) 重建,进化约会和功能注释准确度.

主要方法:

  • 实施了一个以域为中心的管道,包括序列预聚类,多个序列对齐和族系树推断.
  • 使用耐噪声算法来检测物种和重复事件,以构建层次一致的OG.
  • 将工作流应用于来自 12,535 个物种的 5930 万个蛋白质.

主要成果:

  • 与以前的版本相比,生成了318万个正统组 (OG),减少了碎片化和提高了一致性.
  • 与手动策划的KEGG OGs相比,已证明具有更高的功能一致性.
  • 发布了更新的蛋白质功能注释和重新设计的网页界面,增强了搜索和可视化工具.

结论:

  • eggNOG v7通过其强大的家族遗传学,以域为中心的方法,代表了家族遗传学分析的重大进步.
  • 新版本为进化和功能基因组学研究提供了更好的准确性,一致性和可用性.