阴道微生物组和反复和慢性尿路感染
Katie L Dalby1,2, Harry Horsley3, David Spratt4
1Department of Microbial Diseases, Eastman Dental Institute, University College London, London, NW3 2PF, UK. katie.dalby.24@ucl.ac.uk.
International urogynecology journal
|December 8, 2025
概括
阴道微生物组的破坏,特别是乳酸菌的减少,与绝经妇女的复发性尿路感染 (UTI) 有关. 优化阴道生态可能提供非抗生素尿路感染治疗策略.
科学领域:
- 生殖尿道生态学 生殖尿道生态学
- 微生物组研究的研究.
- 妇女健康 妇女健康
背景情况:
- 阴道和尿道微生物之间的联系是已知的,但其在反复和慢性尿路感染 (UTI) 中的作用尚不清楚.
- 研究主要集中在生殖年龄的个体的急性尿路感染,忽视了更年期妇女的慢性病例.
- 性泌尿道与更年期相关的变化增加了对尿路感染的易感性.
研究的目的:
- 审查阴道微生物群破坏对更年期妇女慢性尿路感染的贡献.
- 突出针对这一高风险群体的微生物向干预措施的潜力.
- 强调需要进一步研究生殖尿道微生物组和慢性尿路感染.
主要方法:
- 综合性文献综述,使用与尿路感染,阴道微生物组,更年期和相关疾病相关的搜索术语.
- 根据确定的主题对相关文章进行选,批评和综合.
- 专注于研究性尿生态及其对感染的影响的研究.
主要成果:
- 乳酸菌种对于健康的阴道微生物群至关重要.
- 减少阴道乳酸菌与增加的尿路病原体和尿路感染易感性相关,特别是在更年期.
- 优化阴道生态是一个潜在的非抗生素战略,以减少尿路感染负担和抗菌素耐药性.
结论:
- 受到干扰的阴道生态与更年期妇女的复发性和慢性尿路感染有关.
- 针对微生物组的治疗方法有希望,但需要更多的研究.
- 对慢性和复发性尿路感染群体的有限研究阻碍了临床应用,需要集中研究.
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