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Updated: Jan 9, 2026

Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors
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MNX1通过抑制PERCC1来阻止人类β细胞中的索马托斯塔丁表达

Farah Kobaisi1, Alexis Fouque2, Philippe Ravassard3

  • 1Institut Cochin, CNRS, Inserm, Université Paris Cité, Paris, France. farah.kobaisi@inserm.fr.

Diabetologia
|December 8, 2025
PubMed
概括

运动神经元和胰腺本体箱1 (MNX1) 通过抑制激活体静止素 (SST) 和HHEX表达的PERCC1来保护人类β细胞身份. 这揭示了影响β细胞可塑性的新型调节轴.

关键词:
贝塔细胞的身份 贝塔细胞的身份在HHEX中,它是HHEX.人类胰腺β细胞人类胰腺β细胞在MNX1中,MNX1是MNX1.在 PERRC1 中,这是SST的SST.转录的因素是转录的因素.

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