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Updated: Jan 7, 2026

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E3 乌比奎丁结合酶 TRIM21 通过ASK1 K63-Linked Polyubiquitination加剧病理性心脏缩

Hongjie Shi1,2, Jing Xie1, Sha Hu2

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|December 8, 2025
PubMed
概括

含有21的三方基因 (TRIM21) 通过激活ASK1-JNK/p38 MAPK通路来驱动病态心脏缩. 抑制这个TRIM21-ASK1轴为心脏病提供了潜在的治疗策略.

关键词:
ASK1 是一个问题.这就是MAPKK的意思.在 TRIM2121 中.病理性心脏缩症 病理性心脏缩症通过多元化化化.

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