在患有慢性疼痛的成年人中,医用大麻和阿片类药物接收
Deepika E Slawek1, Chenshu Zhang1, Stephen Dahmer2
1Division of General Internal Medicine, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York.
JAMA internal medicine
|December 8, 2025
概括
参与纽约州医用大麻计划与长期疼痛的成年人在18个月内减少处方阿片类药物的使用有关. 这项研究强调医用大麻是治疗慢性疼痛和减少阿片类药物依赖的潜在选择.
科学领域:
- 疼痛管理 疼痛管理
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 医用大麻越来越多地被探索为治疗慢性疼痛的处方阿片类药物的替代品.
- 由于持续的阿片类药物流行病,迫切需要有效的阿片类药物替代品.
研究的目的:
- 调查纽约州 (NYS) 医用大麻计划的入学与接受处方阿片类药物之间的关联.
- 评估医用大麻使用对患有慢性疼痛的成年人阿片类药物消费的影响.
主要方法:
- 一项队列研究利用了从2018年9月到2023年7月的纽约州处方监测计划 (PMP) 的数据.
- 招募了患有慢性疼痛,处方阿片类药物和新获得纽约州医用大麻认证的成年人.
- 每月的医用大麻分发被监测了18个月,使用边缘结构模型评估处方阿片类药物的接收.
主要成果:
- 总共有204名参与者被纳入,平均年龄为56.8岁.
- 在18个月的随访期间,平均每日吗啡毫等效 (MME) 从73.3降至57.4.4.
- 与没有使用医用大麻相比,分发30天的医用大麻供应与每天3.53MME的减少有关 (P=.03).
结论:
- 参加纽约州医用大麻计划与减少处方阿片类药物接收有关.
- 这些发现表明,医用大麻可能成为治疗慢性疼痛和减轻阿片类药物使用的可行替代方案.
- 该研究在其分析中考虑了自我报告的不受监管的大麻使用.
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