在听觉皮层中快速重新平衡同调合奏活动
HiJee Kang1, Travis A Babola1, Patrick O Kanold1,2
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, United States.
eLife
|December 8, 2025
概括
听觉皮层 (AC) 中的神经元调整其活动以保持对声音的一致感知. 刺激特定的神经元会导致相关的神经元减少活动,平衡网络.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 感官信息是由大脑皮层中的神经元组合处理的.
- 听觉皮层 (AC) 尽管对声音的感知是一致的,但在神经元组合活动中呈现出高的试验对试验的变化.
- 高效的声学处理依赖于稀疏分布的神经元组合中的相互作用.
研究的目的:
- 调查听力皮层中神经元组合内部和跨界的相互作用.
- 为了确定刺激单个细胞如何影响更广泛的皮质网络动态.
- 了解神经元组合相互作用在维护感知恒定的作用.
主要方法:
- 在清醒的小鼠体内进行两光子成像.
- 全息光遗传刺激来激活特定的神经元群体.
- 同时呈现纯色调和有针对性的神经元刺激.
主要成果:
- 在AC中非刺激的同调神经元,当呈现的纯色调频率与他们的调相匹配时,它们的声音唤起的活动会减少.
- 这种活动减少在具有更高频率选择性的同调神经元中更为明显.
- 非协同调节的神经元没有受到影响,协同调节和非协同调节的神经元在空间上相互混合.
- 刺激导致了平衡的总网络活动,该活动保持不变.
结论:
- 听觉皮层中的协同调节的神经元组合通信并积极重新平衡网络活动.
- 这种快速再平衡机制有助于保持网络动态的一致编码.
- 重新平衡的网络活动是持久的,这表明对感知常量的稳定机制.
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