休时间的体育活动,心脏年龄和预测的10年心血管疾病风险之间的剂量反应关系
Yijian Ding1, Xi Xu2, Bingxiang Xu3
1Department of Physical Education, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Xuanwu District, Nanjing 210094, Jiangsu Province, China.
Journal of public health (Oxford, England)
|December 8, 2025
概括
定期的休时间体育活动 (LTPA) 可以降低心脏衰老和心血管疾病 (CVD) 的风险. 充满活力的运动提供了更大的益处,炎症在这种心脏保护作用中发挥了关键的调解作用.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 运动生理学 运动生理学
背景情况:
- 心血管疾病 (CVD) 是一个主要的全球健康问题.
- 休时间的体力活动 (LTPA) 对心血管健康至关重要.
- 了解LTPA和心血管疾病风险因素之间的剂量反应关系至关重要.
研究的目的:
- 调查LTPA与心血管健康之间的剂量反应关系.
- 评估LTPA对心脏年龄和预测10年心血管疾病风险的影响.
- 探索炎症调节在LTPA对心血管健康的影响中的调解作用.
主要方法:
- 使用国家健康和营养检查调查 (2015-2018) 数据对6658名成年人 (30-74岁) 的横截面研究.
- 通用线性回归模型 (GLMs) 和受限立方线分析LTPA与心血管健康的关联.
- 热图可视化用于可变分布评估.
主要成果:
- LTPA显示与心脏年龄的反向关联,预测了10年心血管疾病风险,以及高心血管疾病风险的几率.
- 每个额外的每周一小时的LTPA与心脏年龄减少0.17年和心血管疾病风险减少0.07%相关.
- 强烈强度的LTPA产生了比中度活动更大的心脏保护益处,而炎症则调解了这些效应.
结论:
- LTPA显示了剂量依赖的心脏保护作用.
- 抗炎途径部分调解了LTPA与心血管健康之间的关系.
- 促进LTPA,特别是充满活力的强度活动,对心血管健康至关重要.
相关概念视频
Exercise and Cardiovascular Response
3.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.8K
Factors Influencing Heart Rate
6.1K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
6.1K
Dose-Response Relationship: Overview
4.7K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
4.7K
Coronary Artery Disease IV: Preventive Measures
575
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
575
Lifestyle Factors and Health
395
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
395
Dose-Response Relationship: Potency and Efficacy
6.3K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
6.3K


