认知储备对多发性硬化症或不患多发性硬化症的老年人处理速度和记忆之间的关联产生调解作用
Andrew Fox1, Mark E Wagshul2, Roee Holtzer1
1Ferkauf Graduate School of Psychology, Yeshiva University.
Neuropsychology
|December 8, 2025
概括
认知储备通过调解老年人 (包括患有多发性硬化症 (MS) 患者) 的处理速度和记忆之间的联系,防止记忆衰退. 这凸显了它在维持认知功能的保护作用.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经学 神经学
背景情况:
- 较慢的处理速度与衰老和多发性硬化症 (MS) 中的记忆障碍有关.
- 认知储备作为缓冲对抗认知衰退和痴呆的缓冲.
- 认知储备在处理速度与记忆关系中的调解作用仍然未被研究.
研究的目的:
- 调查认知储备是否调解了老年人处理速度和口头记忆之间的关系.
- 为了确定MS是否会改变认知储备对这种关系的调解作用.
主要方法:
- 患有多发性硬化症的老年人 (n=104) 和健康的对照人 (HCs,n=105) 接受了神经心理测试和MRI.
- 用回归余值计算认知储备.
- 使用符号数字模式测试评估处理速度,使用霍普金斯语言学习测试修订的记忆.
主要成果:
- 认知储备完全介导了处理速度和立即口头记忆回忆之间的关联.
- 认知储备部分介导了处理速度和延迟的口头记忆回忆之间的联系.
- 多发性硬化症状态并没有显著缓解认知储备的调解作用.
结论:
- 认知储备调解了老年人处理速度和记忆性能之间的关系,有或没有MS.
- 这些发现强调了认知储备在缓解记忆力下降方面的保护作用.
- 认知储备是维持整个寿命和神经条件下的记忆功能的一个关键因素.
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