在社区居住的老年人中,STOPPFall药物使用与正静性低血压之间的关联
Kate Doyle1,2,3, Siobhan Scarlett1, Frank Moriarty1,4
1The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland.
Age and ageing
|December 8, 2025
概括
在老年人中,服用两种或两种以上的降落风险增加药物 (FRID) 与延迟血压恢复和静止性低血压 (OH) 有关. 合理化FRID处方对于管理这一群体的OH至关重要.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 心血管医学 心血管医学
背景情况:
- 跌倒风险增加药物 (FRID) 与老年人跌倒风险增加有关.
- 静止性低血压 (OH) 是一个潜在的机制,将FRID与跌倒联系起来.
- 在高跌倒风险的老年人中,老年人处方的查工具 (STOPPFall) 识别了潜在的FRID.
研究的目的:
- 调查STOPPFall药物使用与社区居住的老年人 (≥65岁) 的OH之间的关联.
- 分析STOPPFall药物对站立后血压调节的影响.
主要方法:
- 静止血压 (BP) 是通过使用活跃支架与Finometer测量.
- STOPPFall药物从爱尔兰长距离老化研究 (TILDA) 数据中记录下来.
- 回归模型评估了STOPPFall药物与OH和正静血压变化的各种定义之间的关联.
主要成果:
- 两种或多种STOPPFall药物的处方独立地与延迟血压恢复",任何OH"和经典OH有关.
- 多种STOPPFall药物与静缩血压 (sBP) 显著降低在停顿后的30,60,90和120秒.
- 增加STOPPFall药物的使用与站立后30秒的低血压有关.
结论:
- 处方两种或两种以上的STOPPFall药物与老年人中延迟的BP恢复和OH显著相关.
- 合理化STOPPFall药物适用于患有OH的老年人.
- 这项研究强调了药物审查在预防与OH相关的跌倒方面的重要性.
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